Optogenetic Hyperpolarization of DGC

Arch-EGFP expressing cells undergo hyperpolarization in response to optogenetic stimulation. Membrane potential was quantified using patch clamp in an Arch-EGFP expressing cell ( for different current injection steps) without optogenetic stimulation in A) and with 594nm laser induced optogenetic hyperpolarization in B) (note the decrease in input resistance). C) Optogenetic stimulation did not induce hyperpolarization in a non-labeled wild type cell. D) Hyperpolarization of the cell shown in